The work is made available under the Creative Commons CC0 public domain dedication.ĭata Availability: Study data are available upon request from the Microbicide Trials Network by submission of a Dataset Request Form available at.
#Vaginal ring free
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Received: JAccepted: JanuPublished: February 22, 2022 Karl Malcolm, Queen’s University Belfast, UNITED KINGDOM (2022) Acceptability of an extended duration vaginal ring for HIV prevention and interest in a multi-purpose ring. The 3-month extended duration tenofovir ring for HIV prevention was highly acceptable among women and interest in an MPT was high.Ĭitation: Stoner MCD, Browne EN, Gundacker HM, Hawley I, Chen BA, Hoesley C, et al. Interest in a multi-purpose ring was high (77%) and even higher among those who were sexually active and had male partners. Concerns about hygiene increased over the study period but were often outweighed by the benefits of an extended duration ring. About half felt the ring during sex but most of those participants said it bothered them only a little. Participants perceived the ring to be easy to use, comfortable and reported liking it more over time. The 3-month extended duration tenofovir ring was highly acceptable. We used a mixed methods approach to assess quantitative data on acceptability (n = 49) and used qualitative data from a random subset to explain the quantitative findings (N = 25).
#Vaginal ring trial
This was a secondary analysis of a Phase 1, two-arm, multi-site, placebo-controlled randomized trial evaluating safety and pharmacokinetics of a 90-day vaginal ring containing tenofovir for HIV prevention (N = 49). We evaluated acceptability of a 90-day ring to prevent HIV and hypothetical preferences for a dual (HIV and contraceptive) indication.
Additionally, women have other interlinked sexual health concerns such as unintended pregnancy. Given challenges with adherence to existing HIV prevention products, the development of an extended duration vaginal ring could improve adherence while reducing patient and provider burden.
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